ECOLOGY/EVOLUTION: Radiation Revised

Radiation-induced formation of purine lesions in single and double stranded DNA: revised quantification

The formation of oxidative lesions arising from double stranded DNA damage is of major significance to chemical biology from the perspective of application to human health. The quantification of purine lesions arising from γ-radiation-induced hydroxyl radicals (HO(•)) has been the subject of numerous studies, with discrepancies on the measured 5',8-cyclo-2'-deoxyadenosine (cdA) and 5',8-cyclo-2...

-(revised Version)

AtAPSK_NTD revised

Background: Adenosine 5'-phosphosulfate kinase (APSK) in plants contains a regulatory disulfide bond. Results: Analysis of oxidized APSK reveals altered nucleotide binding compared to the reduced enzyme. Conclusion: The N-terminal domain is responsible for redox-linked structural changes that regulate APSK activity. Significance: This work provides a molecular basis for understanding reciprocal...

Revised draft

In his famous article on “The nature of the firm”, Ronald Coase (1937) sought to answer the question why firms exist, why there are many firms and not just one, why people do not work as individual producers but rather in firms. He suggested that transaction costs could explain the boundaries of the firm and that suggestion later on gave rise to an abundant literature on vertical integration. T...

Neandertals revised.

The last decade has seen a significant growth of our knowledge of the Neandertals, a population of Pleistocene hunter-gatherers who lived in (western) Eurasia between ∼400,000 and 40,000 y ago. Starting from a source population deep in the Middle Pleistocene, the hundreds of thousands of years of relative separation between African and Eurasian groups led to the emergence of different phenotype...